郭瑞 研究员 博导

    郭瑞，男，博士，研究员，第九届广州科技创新南山奖获得者，国家药品监督管理局医疗器械技术审评专家咨询委员会委员，中华医学会组织修复与再生分会第二届委员会青委会委员，广东省药品监督管理局医疗器械注册许可专家，广东省细胞生物学学会常务理事，广东省生物医用材料与临床应用专业委员会委员。科技部、国家自然科学基金委、广东省科技厅、广东省自然资源厅、广州市科技局和广州市工业和信息化局等专家库专家。主要研究方向为：新型组织诱导再生材料的构建及产业化。承担/参与国家重点研发计划政府间国际科技创新合作重点专项、国家重点研发计划、广东省重点研发计划、广州市重点研发计划等省部级以上项目近20项，获批科研经费近2000万元。以第一作者/通讯作者在Biomaterials、Bioactive Materials、Chemical Engineering Journal、Acta Biomaterialia等本领域Top杂志上发表论文80多篇；申请发明专利100多件。获得第二十三届中国专利优秀奖（排名第一），第二十二届中国专利优秀奖（排名第一），第七届广东专利金奖（排名第一）和军队科技进步二等奖（排名第二）各1项。担任Advanced Materials、Advanced Functional Materials、Biomaterials、Theranostics、Acta Biomaterialia、ACS Applied Materials & Interfaces等国际杂志的审稿人。开发的医疗器械产品取得II类注册证3个，另外还有多个II类和III类创新产品正在准备申报资料。

部分学术论文：

1.         Nanbo Liu, Shuoji Zhu, Yuzhi Deng, Ming Xie, Mingyi Zhao, Tucheng Sun, Changjiang Yu, Ying Zhong, Rui Guo*, Keluo Cheng*, Dehua Chang*, Ping Zhu*. Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing. Bioactive Materials.2023, 24:69-80.

2.         Weidong Zhu, Yunqing Dong, Pengcheng Xu, Qiao Pan, Keyao Jia, Panshi Jin, Mou Zhou, Yubing Xu, Rui Guo*, Biao Cheng*. A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice. Acta Biomaterialia. 2022.154, 212-230.

3.         Rui Cai, Meng Wang, Meiyuan Liu, Xiongjie Zhu, Longbao Feng, Zhongjian Yu, Xia Yang, Zhiwu Zhang, Huili Guo, Rui Guo*, Yanfang Zheng *. An iRGD-conjugated photothermal therapy-responsive gold nanoparticle system carrying siCDK7 induces necroptosis and immunotherapeutic responses in lung adenocarcinoma. Bioengineering & Translational Medicine. 2022, https://doi.org/10.1002/btm2.10430.

4.         Peng Luo, Jiarui Fang, Dazhi Yang, Lan Yu, Houqing Chen, Changging Jiang, Rui Guo*, Tao Zhu*, Shuo Tang*. OP3-4 peptide sustained-release hydrogel inhibits osteoclast formation and promotes vascularization to promote bone regeneration in a rat femoral defect model. Bioengineering & Translational Medicine. 2022, https://doi.org/10.1002/btm2.10414.

5.         Chuyao Chen, Shaoshan Huang, Zelong Chen, Qin Liu, Yu Cai, Yingjie Mei, Yikai Xu*, Rui Guo*, Chenggong Yan*. Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration. Bioengineering & Translational Medicine. 2022, http://doi.org/10.1002/btm2.10364.

6.         Lisheng Zhou, Liming Zhou, Chengxiu Wei, Rui Guo*. A bioactive dextran-based hydrogel promote the healing of infected wounds via antibacterial and immunomodulatory. Carbohydrate Polymers. 2022, 291 119558.

7.         Shanghui Huang, Xiangqian Hong, Mingyi Zhaod, Nanbo Liu, Huiling Liu, Jun Zhao, Longquan Shao, Wei Xue, Han Zhang*, Ping Zhu*, Rui Guo*. Nanocomposite hydrogels for biomedical applications. Bioengineering & Translational Medicine. 2022, DOI: 10.1002/btm2.10315.

8.         Liming Zhou, Nanbo Liu, Longbao Feng, Mingyi Zhao, Peng Wu, Yunfei Chai, Jian Liu*, Ping Zhu*, Rui Guo*. Multifunctional electrospun asymmetric wettable membrane containing black phosphorusRg1 for enhancing infected wound healing. Bioengineering & Translational Medicine. 2022; 7(2):e10274.

9.         Shikun Wei, Pengcheng Xu, ZexinYao, Xiao Cui, Xiaoxuan Lei, Linlin Li, Yunqing Dong, WeidongZhu, Rui Guo*, Biao Cheng*. A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes. Acta Biomaterialia. 2021 124, 1 April 2021, 205-218.

10.     Yuanyuan Zheng, Xiangqian Hong, Jiantao Wang, Longbao Fen, Taojian Fan, Rui Guo*, Han Zhang*. 2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines Recent Advances and Future Challenges. Advanced Healthcare Materials. 2021, 10(7): 2001743.

11.     Kui Lu, Keke Li, Min Zhang, Zhaoxin Fang, Panpan Wu, Longbao Feng, Kaixian Deng, Changjiang Yu, Yuzhi Deng, Yang Xiao*, Ping Zhu*, Rui Guo*. Adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) loaded gelatin/silk fibroin hydrogels for improving healing in a murine pressure ulcer model. Chemical Engineering Journal. 2021, 424, 130429.

12.     Xiongjie Zhu, Zhongjian Yu, Longbao Feng, Lian Deng, Zhaobi Fang, Zhile Liu, Ying Li, Xiaoran Wu, Lingyu Qin, Rui Guo*, Yanfang Zheng*. Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer. Carbohydrate Polymers. 2021, 268, 118237.

13.     Huiling Liu, Xiaolan Zhu, Huiming Guo, Huanlei Huang, Shanghui Huang, Shaoshan Huang, Wei Xue, Ping Zhu, Rui Guo*. Nitric oxide released injectable hydrogel combined with synergistic photothermal therapy for antibacterial and accelerated wound healing. Applied Materials Today. 20 (2020) 100781.

14.     Yuanyuan Zheng, Weihao Yuan, Huiling Liu, Shaoshan Huang, Liming Bian, Rui Guo*. Injectable supramolecular gelatin hydrogels loading resveratrol and histatin-1 for burn wound therapy. Biomaterials Science. 2020, 8 (17), 4810-4820.

15.     Shanghui Huang, Huiling Liu, Shaoshan Huang, Tingling Fu, Wei Xue, Rui Guo*. Dextran methacrylate hydrogel microneedles loaded with doxorubicin and trametinib for continuous transdermal administration of melanoma. Carbohydrate Polymers. 246 (15), 2020, 116650.

16.     Shaoshan Huang, Huiling Liu, Kedan Liao, Qinqin Hu, Rui Guo*, Kaixian Deng*. Functionalised GO Nanovehicle with Nitric Oxide Release and Photothermal Activity-Based Hydrogels for Bacteria-Infected Wound Healing. ACS Applied Materials & Interfaces.2020, 12, 26, 28952-28964.

17.     Peng Wang, Shaobin Huang, Zhicheng Hu, Wei Yang, Yong Lan, Jiayuan Zhu, Andrei Hancharou, Rui Guo*,Bing Tang*. In situ formed anti-inflammatory hydrogel loading plasmid DNA encoding VEGF for burn wound healing. Acta Biomaterialia.2019, 100, 191-201.

18.     Yang Wei, Zhu Ping, Huang Huanlei, Zheng Yuanyuan, Liu Jian, Feng Longbao, Guo Huiming*, Tang Shuo*, Rui Guo*. Functionalization of Novel Theranostic Hydrogels with Kartogenin Grafted USPIO Nanoparticles to Enhance Cartilage Regeneration. ACS Applied Materials & Interfaces.2019, 11, 34744-34754.

19.     Hongjie Xu, Shanghui Huang, Jingjing, Wang, Yong Lan, Longbao Feng, Meishu Zhu, Yang Xiao, Biao Cheng, Wei Xue, Rui Guo*. Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells. International Journal of Biological Macromolecules. 2019, 137:433-441.

20.     Yang Xiang, Xiaohui Duan, Longbao Feng, Shuqi Jiang, Li Deng, Jun Shen*, Yijun Yang*, Rui Guo*. tLyp-1-conjugated GSH-sensitive biodegradable micelles mediate enhanced pUNO1-hTRAILa/curcumin co-delivery to gliomas. Chemical Engineering Journal. 2019, 374:392-404.

21.     Wu Zhang, Yuanyuan Zheng, Haixia Liu, Xiao Zhu, Yongchun Gu, Yong Lan, Jiali Tan, Hao Xu*, Rui Guo*. A non-invasive monitoring of USPIO labeled silk fibroin/hydroxyapatite scaffold loaded DPSCs for dental pulp regeneration. Materials Science and Engineering C. 2019, 103:109736.

22.     Lingling Ou, Yong Lan, Zhiqiang Feng, Longbao Feng, Junjie Yang, Yu Liu, Liming Bian, Jiali Tan, Renfa Lai*, Rui Guo*.Functionalization of SF/HAP Scaffold with GO-PEI-miRNA inhibitor Complexes to Enhance Bone Regeneration through Activating Transcription Factor 4.Theranostics. 2019; 9(15):4525-4541.

23.     Jianghui Liu, Liwei Yan, Wei Yang, Yong Lan, Qiyu Zhu, Hongjie Xu, Canbin Zheng*, Rui Guo*. Controlled-release neurotensin-loaded silk fibroin dressings improve wound healing in diabetic rat model. Bioactive Materials.2019, 4:151-159.

24.     Wei Yang, Yuanyuan Zheng, Jie Chen, Qiyu Zhu, Longbao Feng, Yong Lan, Ping Zhu, Shuo Tang*, Rui Guo*. Preparation and characterization of the collagen/cellulose nanocrystals/USPIO scaffolds loaded kartogenin for cartilage regeneration.Materials Science and Engineering C. 2019, 99:1362-1373.

25.     Wei Yang, Hongjie Xu, Yong Lan, Qiyu Zhu, Yu Liu, Shaoshan Huang, Shengjun Shi, Andrei Hancharou, Bing Tang, Rui Guo*. Preparation and characterisation of a novel silk fibroin/hyaluronic acid/sodium alginate scaffold for skin repair. International Journal of Biological Macromolecules.2019, 130:58-67.

个人荣誉：

1. 第九届广州科技创新南山奖，广州市南山自然科学学术交流基金会，2021年5月8日

2. 2014年度广东省高等学校优秀青年教师培养计划

所获奖项：

1. 第二十三届中国专利奖优秀奖，一种促进软骨再生的多孔复合支架及其制备方法，国家知识产权局，2022年4月15日，排名第一，专利号：ZL201710952296.0

2. 第二十二届中国专利奖优秀奖，一种三维多孔复合支架及其制备方法，国家知识产权局，2021年5月10日，排名第一，专利号：ZL201610715160.3

3 第七届广东专利金奖，一种三维多孔复合支架及其制备方法，广东省人民政府，2020年11月，排名第一，专利号：ZL201610715160.3

部分发明专利：

1. 中国专利，郭瑞，张渊明，师忠根，唐渝，一种抗肿瘤纳米药物载体及其制备方法与应用，授权, 2014.12.31，ZL 2013 1 0013665.1

2 中国专利，郭瑞，张渊明，蓝咏，负载万古霉素/明胶微球的丝素蛋白复合支架及其制备方法，授权, 2014.10.29，ZL 2013 1 0031905.0

3 中国专利，郭瑞，张渊明，李卫昌，胶原/纳米纤维素皮肤再生材料及其制备方法与应用，授权，2015.2.11，ZL201310020814.7

4 中国专利，郭瑞，薛巍，冯龙宝，刘璇，一种谷胱甘肽响应型双载药物聚合物胶束及其制备方法与应用，授权，2020.3.17, CN201710271155.2

承担的部分科研项目：

1.         2022年国家重点研发计划政府间国际科技创新合作重点专项（2022YFE0122200），免疫调控水凝胶调节巨噬细胞促进糖尿病创面修复与再生的研究，2023-01-01至2024-12-31，100万。（主持）

2.         2022年国家重点研发计划（2022YFC2403100），课题二：重组人胶原及纤连蛋白的设计、合成与评价（2022YFC2403102），2022-11-01至2025-10-31，160万。（课题负责人）

3.         2022年广东省国际科技合作领域项目（2022A0505050046），负载外泌体的功能化水凝胶促进慢性创面修复的研究，2022-01-01至2023-12-31，50万。（主持）

4.         2019年广东省国际科技合作领域项目（2018A050506040），负载脐带间充质干细胞的抗感染水凝胶修复糖尿病创面的研究，2018-10-01至2020-10-01，100万。（主持）

5.         2019年广州市国际科技合作项目（201907010037），新型MRI/CT双模态3D打印材料负载干细胞精准修复骨缺损的研究，2019-04-01至2022-03-31，200万。（主持）